PF 573228( FAK Inhibitor II | Focal Adhesion Kinase Inhibitor II )

Catalog No. M16313 CAS No. 869288-64-2

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Datasheet

HNMR

HPLC

MSDS

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Product Name

PF 573228
Note

Research use only, not for human use.
Brief Description

PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.
Description

PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.(In Vitro):PF-573228 inhibits purified recombinant catalytic fragment of FAK with an IC50 of 4 nM. In cultured cells, PF-573228 inhibits FAK phosphorylation on Tyr397 with an IC50 of 30-100 nM. Treatment of cells with concentrations of PF-573228 that significantly decreased FAK Tyr397 phosphorylation fails to inhibit cell growth or induce apoptosis. In contrast, treatment with PF-573228 inhibits both chemotactic and haptotactic migration concomitant with the inhibition of focal adhesion turnover.
In Vitro

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In Vivo

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Synonyms

FAK Inhibitor II | Focal Adhesion Kinase Inhibitor II
Pathway

Tyrosine Kinase
Target

FAK
Recptor

FAK
Research Area

Cancer
Indication

——

CAS Number

869288-64-2
Formula Weight

491.49
Molecular Formula

C22H20F3N5O3S
Purity

>98% (HPLC)
Solubility

DMSO: 26 mg/mL (52.9 mM)
SMILES

O=C1NC2=C(C=C(NC3=NC=C(C(F)(F)F)C(NCC4=CC=CC(S(=O)(C)=O)=C4)=N3)C=C2)CC1
Chemical Name

3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone

1.Slack-Davis JK, et al. J Biol Chem, 2007, 282(20), 14845-14852.

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